{"id":5366,"date":"2024-05-09T18:23:58","date_gmt":"2024-05-09T18:23:58","guid":{"rendered":"https:\/\/acuiteqc.ca\/?page_id=5366"},"modified":"2026-03-17T04:34:10","modified_gmt":"2026-03-17T04:34:10","slug":"aims","status":"publish","type":"page","link":"https:\/\/acuiteqc.ca\/?page_id=5366","title":{"rendered":"Aims"},"content":{"rendered":"<div class=\"brz-root__container brz-reset-all brz brz-root__container-page\">\n<section id=\"_oeq34ISYFVpt\" class=\"brz-section brz-section__header brz-css-1oxtq3q\">\n<div class=\"brz-section__header--animated brz-css-1oxtq3q\">\n<div class=\"brz-section__header-sticky-item brz-css-4lfxbw\" data-brz-custom-id=\"ezSyT01TX2BH\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-1xkz3p1 brz-css-ongfd7\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-menu__container brz-css-geldhb\" data-mmenu-id=\"#mzNjXgk0ELK2_\" data-mmenu-position=\"position-left\" 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class=\"brz-menu__item \"><a class=\"brz-a\" target=\"\" href=\"\" title=\"\"><span class=\"brz-span\"><\/span><\/a>\n<ul class=\"brz-menu__sub-menu\"><\/ul>\n<\/li>\n<\/ul>\n<\/nav>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-section__menu-item brz-css-1mm3h2w brz-css-1npsxp4\" data-brz-custom-id=\"pKCe5sXx1qBA\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-ytvhvq\">\n<div class=\"brz-row__container brz-css-rdiscf\" data-brz-custom-id=\"hvyCiL7CDMqm\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-row brz-css-1xqkplf brz-css-13rhcny\">\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-3537jg\" data-brz-custom-id=\"dRMX_mwoqlA7\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-18q3ks3\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-css-1vf2lbo brz-wrapper\">\n<div class=\"brz-image brz-css-18fk5yz\" data-brz-custom-id=\"blElLhT1AsGi\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/acuiteqc.ca\/wp-content\/uploads\/brizy\/imgs\/cropped-logo_acuite_qc_couleur_fr-e1645818657209-223x90x0x0x223x90x1709149228.png\" alt=\"\" loading=\"lazy\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-1w9bugl\" data-brz-custom-id=\"kkjUs6D827Ia\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-1tdbdax\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-menu__container brz-css-geldhb brz-css-14jolsl\" data-mmenu-id=\"#h267ZRog6I4b_\" data-mmenu-position=\"position-left\" data-mmenu-title=\"Main Menu\" data-mmenu-stickytitle=\"on\" data-mmenu-closingicon=\"%7B%22desktop%22%3A%22off%22%2C%22tablet%22%3A%22off%22%2C%22mobile%22%3A%22off%22%7D\" data-brz-custom-id=\"h267ZRog6I4b\">\n<nav data-mods=\"%7B%22desktop%22%3A%22horizontal%22%2C%22tablet%22%3A%22horizontal%22%2C%22mobile%22%3A%22horizontal%22%7D\" class=\"brz-menu brz-menu__preview brz-css-1gefmeq brz-css-gx26jj\">\n<ul class=\"brz-menu__ul\" data-menu-items-active=\"\">\n<li data-menu-item-id=\"\" class=\"brz-menu__item \"><a class=\"brz-a\" target=\"\" href=\"\" title=\"\"><span class=\"brz-span\"><\/span><\/a>\n<ul class=\"brz-menu__sub-menu\"><\/ul>\n<\/li>\n<\/ul>\n<\/nav>\n<div class=\"brz-mm-menu__icon\"><\/div>\n<nav data-mods=\"%7B%22desktop%22%3A%22horizontal%22%2C%22tablet%22%3A%22horizontal%22%2C%22mobile%22%3A%22horizontal%22%7D\" id=\"h267ZRog6I4b_\" class=\"brz-menu brz-menu__preview brz-menu__mmenu brz-css-r7lq7 brz-css-1tsanu1\">\n<ul class=\"brz-menu__ul\" data-menu-items-active=\"\">\n<li data-menu-item-id=\"\" class=\"brz-menu__item \"><a class=\"brz-a\" target=\"\" href=\"\" title=\"\"><span class=\"brz-span\"><\/span><\/a>\n<ul class=\"brz-menu__sub-menu\"><\/ul>\n<\/li>\n<\/ul>\n<\/nav>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-2725ce\" data-brz-custom-id=\"tpIRud3cOeQU\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-1u9ajro\">\n<div class=\"brz-wrapper-clone brz-css-1f4aj8c brz-css-jxjf5d\">\n<div class=\"brz-d-xs-flex brz-flex-xs-wrap brz-css-1u8rxzx brz-css-1ioj2g\" data-brz-custom-id=\"\">\n<div class=\"brz-wrapper-clone__item\" id=\"f4lb7ZGItAtv\">\n<div class=\"brz-icon__container\" data-brz-custom-id=\"f4lb7ZGItAtv\"><a class=\"brz-a\" href=\"https:\/\/www.linkedin.com\/showcase\/institut-de-pharmacologie-de-sherbrooke\/?viewAsMember=true\" target=\"_self\" rel=\"noopener\" data-brz-link-type=\"external\"><span class=\"brz-icon brz-span brz-css-1em4ig1 brz-css-1450hfa\"><\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"_lg2ZTAzcclmu\" class=\"brz-section brz-css-oi8982\">\n<div class=\"brz-section__content brz-section--boxed brz-css-qbz7jp\" data-brz-custom-id=\"cAqMV65xV1BX\">\n<div class=\"brz-container brz-css-1c1uhe9\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"hmSTQxPE5HUJ\">\n<div data-brz-translate-text=\"1\">\n<h1 data-uniq-id=\"mcEzm\" data-generated-css=\"brz-css-sfnto\" class=\"brz-tp-lg-heading1 brz-text-lg-center brz-css-pxOlR\"><span class=\"brz-cp-color4\">Acuity Quebec project&rsquo;s aims<\/span><\/h1>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"dzjgspK_1ehn\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-aJgO9\" data-generated-css=\"brz-css-tc7Zs\" data-uniq-id=\"qCRSg\"><span class=\"brz-cp-color7\">The Acuity Quebec project has 4 objectives and involves several experts from the Universit\u00e9 de Sherbrooke, as well as researchers from the Institute for Research in Immunology and Cancer (IRIC) and the Institut qu\u00e9b\u00e9cois d&rsquo;intelligence artificielle (Mila). Their mission? To improve the acuity of the drug discovery process, in particular by integrating the potential of artificial intelligence (AI) into all stages of the research process.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-rdiscf\" data-brz-custom-id=\"wAK31g5ad_Pz\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-row brz-css-1xqkplf brz-css-n3xl6v\">\n<div class=\"brz-columns brz-css-1ta6es2\" data-brz-custom-id=\"cLBYWEHqRiQT\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-jak6x2\">\n<div class=\"brz-row__container brz-css-rdiscf\" data-brz-custom-id=\"mDDMHo3h6t0c\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-row brz-row--inner brz-css-1xqkplf brz-css-n3xl6v\">\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-1t7jfwu\" data-brz-custom-id=\"uUHE8OjsAm0b\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-1hf1bxu\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-image brz-css-rkrfhj brz-css-1khq5du\" data-brz-custom-id=\"nQHgxNrXHSWz\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/acuiteqc.ca\/wp-content\/uploads\/2024\/03\/pexels-rfstudio-3825572-scaled.jpg\" alt=\"\" loading=\"lazy\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-css-11zbjyf brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"xlLLhNheQ3km\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-lg-center brz-tp-lg-heading2 brz-css-dAlqP\" data-generated-css=\"brz-css-oZr9Z\" data-uniq-id=\"exWCn\"><span class=\"brz-cp-color3\">Innovative compounds<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-accordion brz-css-1vkws56 brz-css-gd4zdc\" data-brz-duration=\"300\" data-brz-custom-id=\"cxHjNgqHvPgN\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Context<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"bU1zNluxuasO\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-lz4dS\" data-uniq-id=\"u903B\" data-generated-css=\"brz-css-p9qNp\"><span class=\"brz-cp-color7\">Around 75% of drugs approved in 2018 belong to the small molecule, peptide or monoclonal antibody categories. <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-ximz6\" data-uniq-id=\"d_w7q\" data-generated-css=\"brz-css-uOd3i\"><span class=\"brz-cp-color7\">The identification and optimization of small molecules is multi-parametric and akin to a multi-dimensional puzzle in a massive chemical space (~1030-1060 molecules), whereas conventional libraries have only around 106 compounds. The identification of quality ligands with high structural diversity is therefore essential.<\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-sTfod\" data-uniq-id=\"m1E29\" data-generated-css=\"brz-css-fKA63\"><span class=\"brz-cp-color7\">Peptides, on the other hand, offer a number of advantages and disadvantages. They are easily diversified using solid-phase synthesis to decipher their structure-activity relationship (SAR). However, their physicochemistry makes them unsuitable for intracellular targets or oral absorption. <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-qKodA\" data-uniq-id=\"bVlTW\" data-generated-css=\"brz-css-t1X54\"><span class=\"brz-cp-color7\">Finally, monoclonal antibodies are a rapidly expanding class of drugs, but their development for GPCRs and other membrane proteins remains a challenge.<\/span><\/p>\n<p class=\"brz-tp-lg-paragraph brz-css-rFYpn\" data-uniq-id=\"uBkl2\" data-generated-css=\"brz-css-wnRkQ\"><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-accordion__item brz-accordion__item--active\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Projects in this area<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"vzNpPOioMcqB\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-jta02\" data-generated-css=\"brz-css-mhNu2\" data-uniq-id=\"liWOR\"><strong class=\"brz-cp-color4\">Compound librairies<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"vsOLhab6NhT6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-yMrIq\" data-generated-css=\"brz-css-bJUis\" data-uniq-id=\"qM5Cc\"><span class=\"brz-cp-color7\">We aim to create innovative libraries encoded by new DNA heads and refined by artificial intelligence (AI) to expand chemical space and maximize diversity.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"dFYaerqGmvv6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-mZxzp\" data-uniq-id=\"zsNVu\" data-generated-css=\"brz-css-sYoFg\"><strong class=\"brz-cp-color4\">Peptides<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"ssMKtopZCNa2\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-eNzJ0\" data-generated-css=\"brz-css-qBN9E\" data-uniq-id=\"rzqDX\"><span class=\"brz-cp-color7\">This objective aims to use peptides to rapidly establish the structure-activity relationship, and then harness AI to transform peptide leads into small drug-like molecules. We will integrate properties such as lipophilicity, polar surface, metabolic stability, solubility, toxicophores, synthesis, etc. from the outset. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"eniVrGnfuSkj\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-p5wXA\" data-generated-css=\"brz-css-zB9e8\" data-uniq-id=\"o5Qc9\"><strong class=\"brz-cp-color4\">Antibodies<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"up3hQa_vh6Yo\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-sCV15\" data-generated-css=\"brz-css-qZYAS\" data-uniq-id=\"kpRKs\"><span class=\"brz-cp-color7\">We aim to perfect a technology for optimizing superior antibodies for GPCRs and other complex targets, all using macrocycle epitope mimicry technology. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-wrapper-clone brz-css-1f4aj8c\">\n<div class=\"brz-d-xs-flex brz-flex-xs-wrap brz-css-1u8rxzx\" data-brz-custom-id=\"\">\n<div class=\"brz-wrapper-clone__item\" id=\"c2Mw5zENTHPp\"><a class=\"brz-a brz-btn brz-css-lbyo9g brz-css-1hat942 brz-css-6s5t42 brz-css-1po2of3\" href=\"\" target=\"_self\" rel=\"noopener\" data-brz-link-type=\"page\" data-brz-custom-id=\"c2Mw5zENTHPp\"><span data-brz-translate-text=\"1\" class=\"brz-span brz-text__editor\">Learn more<\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-1ntbipl\" data-brz-custom-id=\"hHzzJSIbCwJo\">\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-1govv8t\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-image brz-css-16vvpow brz-css-13gsmfd\" data-brz-custom-id=\"rJAcu7vAMq0h\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/acuiteqc.ca\/wp-content\/uploads\/2024\/03\/pexels-photo-6941883-scaled.jpeg\" alt=\"\" loading=\"lazy\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-css-18669b7 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"j4dY2Lsizb8l\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-lg-center brz-tp-lg-heading2 brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_6 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-20 brz-ft-google brz-ff-overpass ql-align-center brz-css-cjLq8\" data-uniq-id=\"iO1cj\" data-generated-css=\"brz-css-l64Dy\"><span class=\"brz-cp-color1\">Next-generation biosensors<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-accordion brz-css-1vkws56 brz-css-o0nkk7\" data-brz-duration=\"300\" data-brz-custom-id=\"a5jPp1ur_WNz\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Context<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"iU2N960asFAk\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-lJmWF\" data-uniq-id=\"bsmjH\" data-generated-css=\"brz-css-jxTNd\"><span class=\"brz-cp-color7\">A candidate molecule must satisfy multiple requirements to become a drug (e.g. interaction with the target, distribution to the site of action, non-toxicity, physicochemical profile, metabolic stability, etc.). <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-pGdb7\" data-uniq-id=\"bsmjH\" data-generated-css=\"brz-css-jxTNd\"><span class=\"brz-cp-color7\"> <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-fwck9\" data-uniq-id=\"ab7F9\" data-generated-css=\"brz-css-hpJWk\"><span class=\"brz-cp-color7\">Drug action (pharmacodynamics) is the sum of combined responses across signaling pathways, cells and tissues. It is modulated by pharmacokinetics (PK-ADME, the body&rsquo;s absorption mechanisms that distribute, metabolize and excrete drugs). <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-css-o8bGE\" data-uniq-id=\"zE4Z3\" data-generated-css=\"brz-css-zm1RX\"><\/p>\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-tp-lg-empty brz-css-xZ6sE\" data-uniq-id=\"qeTHr\" data-generated-css=\"brz-css-x5E9r\"><span class=\"brz-cp-color7\">At the cellular level, a molecule elicits a range of responses, some leading to desired effects, others to undesirable ones. Obtaining comprehensive signaling profiles with predictive therapeutic value from signaling profiles is a challenge that the consortium aims to meet. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-accordion__item brz-accordion__item--active\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Projects in this area<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"tgnVElmxbeIc\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-umGnE\" data-uniq-id=\"rfuNO\" data-generated-css=\"brz-css-unOUg\"><strong class=\"brz-cp-color1\">Next-generation biosensors<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"vE4BTjIG3Dfs\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-t6re3\" data-generated-css=\"brz-css-j9qKE\" data-uniq-id=\"szKcY\"><span class=\"brz-cp-color7\">We will develop next-generation biosensors for comprehensive spatio-temporal reporting of cellular response in multiple cell types (in vivo).<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"zjR1c2vpbbZr\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-m4g29\" data-uniq-id=\"gNYL2\" data-generated-css=\"brz-css-mhjpY\"><strong class=\"brz-cp-color1\">ML procedures<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"deIk64OgfLYa\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-w1p_s\" data-generated-css=\"brz-css-flz74\" data-uniq-id=\"dRBxU\"><span class=\"brz-cp-color7\">This objective aims to develop ML-based procedures for associating in vitro response sets with in vivo pharmacological responses, applied to cannabinoids.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"sB6_bSoy0ZQ2\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-tp-lg-empty brz-css-f2UTd\" data-generated-css=\"brz-css-qIGPI\" data-uniq-id=\"mCPnN\"><strong class=\"brz-cp-color1\">Pharmacokinetic biosensors<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"qsF95LsFs0lm\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-ak5yp\" data-generated-css=\"brz-css-aaq6H\" data-uniq-id=\"xnIbt\"><span class=\"brz-cp-color7\">The aim of this sub-objective is to create real-time pharmacokinetic biosensors to assess (pre)clinical drug levels.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-wrapper-clone brz-css-1f4aj8c\">\n<div class=\"brz-d-xs-flex brz-flex-xs-wrap brz-css-1u8rxzx\" data-brz-custom-id=\"\">\n<div class=\"brz-wrapper-clone__item\" id=\"iuIEV7Hvs7yM\"><a class=\"brz-a brz-btn brz-css-lbyo9g brz-css-1t16msd brz-css-6s5t42 brz-css-5pmls8\" href=\"\" target=\"_self\" rel=\"noopener\" data-brz-link-type=\"page\" data-brz-custom-id=\"iuIEV7Hvs7yM\"><span data-brz-translate-text=\"1\" class=\"brz-span brz-text__editor\">Learn more<\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-1ta6es2\" data-brz-custom-id=\"sozIuF8okWHm\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-jak6x2\">\n<div class=\"brz-row__container brz-css-rdiscf\" data-brz-custom-id=\"bD4mYaG3IRpt\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-row brz-row--inner brz-css-1xqkplf brz-css-n3xl6v\">\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-1uq5maf\" data-brz-custom-id=\"rMNFOPJuZNCl\">\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-jzr3yd\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-image brz-css-1sy8r7m brz-css-107dw4v\" data-brz-custom-id=\"mMpqinPWQhbB\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/acuiteqc.ca\/wp-content\/uploads\/2024\/03\/telechargement-12.jpg\" alt=\"\" loading=\"lazy\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-css-o8wu29 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"z3hTEdvFI1MW\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-lg-center brz-tp-lg-heading2 ql-align-center brz-css-seBlr\" data-uniq-id=\"xcJc8\" data-generated-css=\"brz-css-o9khT\"><span class=\"brz-cp-color4\">Advanced imaging<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-accordion brz-css-1vkws56 brz-css-156par6\" data-brz-duration=\"300\" data-brz-custom-id=\"eShuwzoVzqHt\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Context<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"n1Gs6Dy54208\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-tp-lg-empty brz-css-l8N9s\" data-generated-css=\"brz-css-v3qY3,brz-css-pTvNb,brz-css-clmPV,brz-css-up4V0,brz-css-e23AW,brz-css-sWztD\" data-uniq-id=\"b7oL5,jf4lX,bk3c8,bzUM0,j_1CY,purf4\"><span class=\"brz-cp-color7\">Accurate imaging of target distribution, expression or engagement, and drug response in vivo, is essential for understanding the efficacy and safety of a therapy. <\/span><\/p>\n<p class=\"brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-tp-lg-empty brz-css-vhyNj\" data-generated-css=\"brz-css-v3qY3,brz-css-pTvNb,brz-css-clmPV,brz-css-up4V0,brz-css-e23AW,brz-css-sWztD\" data-uniq-id=\"b7oL5,jf4lX,bk3c8,bzUM0,j_1CY,purf4\"><\/p>\n<p class=\"brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-tp-lg-empty brz-css-tY_aK\" data-generated-css=\"brz-css-v3qY3,brz-css-pTvNb,brz-css-clmPV,brz-css-up4V0,brz-css-e23AW,brz-css-sWztD\" data-uniq-id=\"b7oL5,jf4lX,bk3c8,bzUM0,j_1CY,purf4\"><span class=\"brz-cp-color7\">Despite great advances in medical imaging, the technologies are mainly used in clinical diagnostics and rarely in drug discovery.<\/span><\/p>\n<p class=\"brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-tp-lg-empty brz-css-h6HWg\" data-generated-css=\"brz-css-v3qY3,brz-css-pTvNb,brz-css-clmPV,brz-css-up4V0,brz-css-e23AW,brz-css-sWztD\" data-uniq-id=\"b7oL5,jf4lX,bk3c8,bzUM0,j_1CY,purf4\"><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-sdtqw\" data-generated-css=\"brz-css-sWztD\" data-uniq-id=\"purf4\"><span class=\"brz-cp-color7\">Current approaches do not allow us to know precisely how and where drugs are distributed, whether the target is engaged, whether response takes place in the target tissue or toxicity in a non-target tissue. Imaging technologies can provide these answers. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-accordion__item brz-accordion__item--active\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Projects in this area<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"f90DqX9fM9F3\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-pff5H\" data-generated-css=\"brz-css-g4xCB\" data-uniq-id=\"oqdr_\"><strong class=\"brz-cp-color6\">AI in imaging<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"yvotcVrq3ih9\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-xM86s\" data-generated-css=\"brz-css-dGzVa,brz-css-rMklv,brz-css-ciAF6\" data-uniq-id=\"e7LfR,sGOHP,aM0H_\"><span class=\"brz-cp-color7\">We aim to develop precise imaging at preclinical and clinical stages that will accelerate drug development while enabling precision medicine.<\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-izfDC\" data-generated-css=\"brz-css-dGzVa,brz-css-rMklv,brz-css-ciAF6\" data-uniq-id=\"e7LfR,sGOHP,aM0H_\"><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-cx9Nl\" data-generated-css=\"brz-css-ciAF6\" data-uniq-id=\"aM0H_\"><span class=\"brz-cp-color7\">We will progress by using AI to provide ultra-high resolution imaging of the brain.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"vWNiNm50NNpm\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-rCZaN\" data-generated-css=\"brz-css-o08yt\" data-uniq-id=\"bUqLa\"><strong class=\"brz-cp-color6\">PET Scan<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"kTR8O1D99UBH\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-li7_p\" data-generated-css=\"brz-css-b2CWi\" data-uniq-id=\"nqRTQ\"><span class=\"brz-cp-color7\">This sub-objective will enable the design of positron emission tomography (PET) tracers to assess the cerebral distribution of drug candidates.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"a680D7tgR_fW\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-tp-lg-empty brz-css-aG7sk\" data-uniq-id=\"zE6RI\" data-generated-css=\"brz-css-bjyqh\"><strong class=\"brz-cp-color6\">MRI technology<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"vY7eaJaxDH7g\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-jVnQP\" data-generated-css=\"brz-css-peSNc\" data-uniq-id=\"dQm0B\"><span class=\"brz-cp-color7\">This sub-objective will be used to create a diffusion MRI (dMRI) reference map for neurodegenerative diseases.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"qw_SXzlhu_WV\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_9 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-16 brz-ft-google brz-ff-overpass brz-tp-lg-empty brz-css-jgMJk\" data-uniq-id=\"zJQoJ\" data-generated-css=\"brz-css-qd3qy\"><strong class=\"brz-cp-color6\">Treatment decision<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"bhiD23ihI9RZ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-alF1B\" data-generated-css=\"brz-css-mZYsE\" data-uniq-id=\"ad2nm\"><span class=\"brz-cp-color7\">We will develop an MRI image analysis procedure. High-resolution imaging combined with PET tracers and anatomical or functional brain maps will provide unprecedented acuity in these areas, supporting drug development for neurological disorders. The latter field suffers from frequent and costly failures. The addition of AI to key stages of the PET imaging process, from radiation detection to image correction and analysis, will increase resolution and sensitivity.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-wrapper-clone brz-css-1f4aj8c\">\n<div class=\"brz-d-xs-flex brz-flex-xs-wrap brz-css-1u8rxzx\" data-brz-custom-id=\"\">\n<div class=\"brz-wrapper-clone__item\" id=\"nHEoZgWde_zr\"><a class=\"brz-a brz-btn brz-css-lbyo9g brz-css-1wc609v brz-css-6s5t42 brz-css-163q0sw\" href=\"\" target=\"_self\" rel=\"noopener\" data-brz-link-type=\"page\" data-brz-custom-id=\"nHEoZgWde_zr\"><span data-brz-translate-text=\"1\" class=\"brz-span brz-text__editor\">Learn more<\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-1ta6es2 brz-css-1pbwg3l\" data-brz-custom-id=\"skFk5qBIdhLf\">\n<div class=\"brz-column__items brz-css-jak6x2 brz-css-1soydyb\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-image brz-css-k80xg5 brz-css-19wy8q8\" data-brz-custom-id=\"tw5wS_XywVYI\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/acuiteqc.ca\/wp-content\/uploads\/2024\/03\/pexels-photo-8386440-scaled.jpeg\" alt=\"\" loading=\"lazy\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-css-hne2iq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"wk4sYve9MsU1\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-tp-lg-heading2 ql-align-center brz-css-hyMFH\" data-uniq-id=\"zEBfo\" data-generated-css=\"brz-css-p6gOb\"><span class=\"brz-cp-color6\">Algorithms<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-accordion brz-css-1vkws56 brz-css-vyk3r\" data-brz-duration=\"300\" data-brz-custom-id=\"bV6NFw0LOlXI\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Context<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"mKQDzHTioMRh\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-p80fV\" data-generated-css=\"brz-css-m1PTp\" data-uniq-id=\"s6ReD\"><span class=\"brz-cp-color7\">The deployment of artificial intelligence (AI) as part of the Acuit\u00e9 Qu\u00e9bec consortium will be supported by an outstanding team of scientists from the Mila Institute led by Dr. Yoshua Bengio. The team will refine solutions for drug design and optimization, signaling analysis with biomarkers and imaging platforms.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-accordion__item brz-accordion__item--active\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"on\">\n<h3 data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-h3 brz-text__editor\">Projects in this area<\/h3>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"mGXqpgM3fY8Y\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-gC_Zq\" data-uniq-id=\"tNKF2\" data-generated-css=\"brz-css-ruUX_\"><strong class=\"brz-cp-color5\">Common software supported by AI<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-3ihiwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-1c54op8\" data-brz-custom-id=\"d9F5lLZO0jks\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-aQkKd\" data-generated-css=\"brz-css-lFiCG,brz-css-z8F5v,brz-css-mjiQm,brz-css-zftpi,brz-css-gS0r4,brz-css-hRinP,brz-css-mitKQ,brz-css-toZiM\" data-uniq-id=\"on5tB,pLdaH,fK10b,xpLiA,xYDlt,vXdaH,qRc_R,qOL1Z\"><span class=\"brz-cp-color7\">The aim is to develop common software that will enable AI techniques to be applied to any drug development problem. AI approaches will be based on active learning methods taking advantage of iterative feedback between proposed candidates and experimental results.<\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-dMYwm\" data-generated-css=\"brz-css-lFiCG,brz-css-z8F5v,brz-css-mjiQm,brz-css-zftpi,brz-css-gS0r4,brz-css-hRinP,brz-css-mitKQ,brz-css-toZiM\" data-uniq-id=\"on5tB,pLdaH,fK10b,xpLiA,xYDlt,vXdaH,qRc_R,qOL1Z\"><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-lodDz\" data-generated-css=\"brz-css-lFiCG,brz-css-z8F5v,brz-css-mjiQm,brz-css-zftpi,brz-css-gS0r4,brz-css-hRinP,brz-css-mitKQ,brz-css-toZiM\" data-uniq-id=\"on5tB,pLdaH,fK10b,xpLiA,xYDlt,vXdaH,qRc_R,qOL1Z\"><span class=\"brz-cp-color7\">The aim of this project is to enable the prioritization of computational and analytical resources in order to maximize the information gained about future candidates, with the potential to significantly accelerate drug discovery. In particular, we will develop solutions for smaller datasets than those normally used in AI, taking advantage of the multimodal information available.<\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-uZdZs\" data-generated-css=\"brz-css-lFiCG,brz-css-z8F5v,brz-css-mjiQm,brz-css-zftpi,brz-css-gS0r4,brz-css-hRinP,brz-css-mitKQ,brz-css-toZiM\" data-uniq-id=\"on5tB,pLdaH,fK10b,xpLiA,xYDlt,vXdaH,qRc_R,qOL1Z\"><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-overpass brz-ft-google brz-fs-lg-16 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1_9 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-b5pvR\" data-generated-css=\"brz-css-toZiM\" data-uniq-id=\"qOL1Z\"><span class=\"brz-cp-color7\">Machine learning (ML) will be used to transform examples into predictors and decision policies for drug development to identify molecules with specific properties. 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Their mission? 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